A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein.
BACKGROUND: Mammals have seven NAD-dependent protein deacetylases.These proteins, called sirtuins, are homologous click here to yeast Sir2, and are emerging as important regulators of lifespan and intermediary metabolism.Three mammalian sirtuins, SIRT3-5 are mitochondrial.Sirtuins are highly conserved between species, yet mouse SIRT3 was reported t